Additive Manufacturing Technologies (AMT)
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Guided Vascularization

Vascularization is the process of formation of blood vessels inside a living tissue. This is particularly important in tissue engineering and regenerative medicine, in order for nutrients to reach the cells in large tissue constructs. Especially for in-vitro models, such as organ-on-chips, a precisely controlled vascularization is fundamental to obtaining a complex and interconnected multi-tissue systems where, besides nutrients, also drugs and hormones can be transported.

We exploit high-resolution 3D printing in order to create defined patterns, helping cells to organise and migrate, and finally produce micro-vascular networks inside a cell-supporting hydrogel matrix. The resulting cell sprouting is referred to as guided vascularization and holds great potential for engineering of 3D tissue models, as well as tissue regeneration.